The Andromeda Strain by Michael Crichton (1969)

The human body is one of the dirtiest things in the known universe (p.116)

Michael Crichton

I’ve no idea what Crichton was like as a man but I admire his phenomenal success as a writer of popular techno-thrillers. If you’re going to entertain, then you might as well do it as effectively as possible. Ever since I learned about it years ago, I’ve been impressed by what will probably be a unique feat that no-one will ever match, namely that in 1994 Crichton was, simultaneously, the writer of America’s number one movie, Jurassic Park, was the creator and producer of America’s number one TV show, ER, and had a book at number one in the bestseller list, Disclosure.

What an amazing achievement and indicator of the practical skills of a man who was not only an author and scriptwriter, but who produced and directed movies himself, as well as creating and exec producing hit TV series.

The Andromeda Strain

Right back at the start of his career, young Michael (born 1942), was 26 when he published this, the first novel to appear under his own name (a few had appeared under pseudonyms). It announces a major talent, not so much in the plot – space probe returns to earth carrying a deadly virus is the same as, say, The Quatermass Experiment – but in the thoroughness and the verisimilitude of the scientific and administrative framework he presents the story in.

The story begins by describing the arrival of a two-man recovery team (Lieutenant Shawn and Private Lewis Crane) to retrieve a space probe which has crash landed on the small town of Piedmont in Arizona (population 48). They’re in the middle of doing so when their radio message back to base is dramatically cut short. Alerts are transmitted up the chain of command until five scientists who have been kept on standby for just such an emergency are each visited at home in the middle of the night by dark-suited security officials, asked to accompany them immediately in unmarked cars to military airports and flown to the top secret biohazard unit in the Nevada desert which has been painstakingly constructed for just such an emergency, under the codename Project Wildfire.

The scientists are:

  • Dr. Jeremy Stone: Professor and chair of the bacteriology department at Stanford University, fictitiously the winner of the 1961 Nobel Prize in Physiology or Medicine
  • Dr. Charles Burton, 54 (p.61) Professor of Pathology at the Baylor College of Medicine, ‘nervous, jumpy, petulant’, nicknamed the Stumbler (p.54)
  • Dr. Peter Leavitt ‘superb clinical bacteriologist’ (p.59) who suffers from epilepsy, ‘an irritating, grumbling, heavyset man’ (p.54)
  • Dr. Mark Hall, surgeon
  • Professor Christian Kirke, who never makes an appearance because he’s in hospital for appendicitis

The plot then follows the scientists’ race against time to identify the weird extra-terrestrial virus and try to find a cure. The breakneck plot builds up to a climax when there’s a breach in biosecurity at the Wildfire centre with the result so that the virus gets loose among our heroes, and there’s a race against time to prevent its spread… with a novel twist at the very end.

So much for the thrilling plot, but what really distinguishes the text, and makes Crichton’s debut stand out, is the enormous amount of scientific, technical and administrative content.

Organisations

For example, the book is packed with dense and authoritative-sounding explanations of the umpteen different branches of the US military, space agency and security services which were involved in the research, commissioning, financing and building of the biohazard centre, including:

  • Vandenberg Scoop Mission Control
  • The National Aeronautics and Space Administration
  • the Wildfire facility is built by the Electric Boat Division of General Dynamics
  • the Army Medical Corps, Chemical and Biological Warfare Division
  • the Senate Preparedness Subcommittee
  • the Goddard Spaceflight Centre
  • the President’s Scientific Advisory Committee

Official documentation

Lots of pages of the text consist of ‘copies’ or apparent photostats of official documents, procedures, maps, computer projections and so on, for example a photocopy of the original letter written by concerned scientists to the President of the United States suggesting the creation of a quarantined biohazard centre. It was here, right back at the start of the project, that the scientists included the controversial suggestion of having a small thermonuclear device onsite, which could be detonated if the infection gets out of control (under Directive 7-12, codename Cautery).

In fact soon after Stone and Burton have investigated the town (wearing tip-top latest biohazard suits) and discover an old man still alive and a screaming baby and retrieve them into a helicopter and take them back to the Wildfire centre, Piedmont is itself destroyed by a small nuclear weapon (p.114).

Scientific references

Then, complementing the detailed descriptions of security organisations there is the science itself. It includes references to:

  • a fictional study by J.J. Merrick an English biophysicist on the likelihood of extra-terrestrial life and the probability of it being single-cell life
  • a study by the Hudson Institute on the likely outcome of various scenarios around an alien infection outbreak and the impact of detonating a nuclear weapon to obliterate it (p.87)
  • a two-page study complete with statistical analysis, of the Odd Man Out Hypothesis
  • a study by Rudolph Karp who established there are life forms on meteors and asteroids (p.130)
  • the Vector Three report which identified three possible sources for extra-terrestrial bacteria
  • the Messenger Theory of John R. Samuels i.e. that an intelligent civilisation on another planet might choose to communicate not by sending radio or TV signals but sending out tough microforms of life which can recombine if they ever arrive somewhere inhabitable (p.228)
  • a 274-page report on Project Wildfire, highlights of which Dr Hall has to read;  through to detailed descriptions of American military research into chemical and biological weaponry, with lists of the major research universities involved and some of the papers produced on the subject:

Few Americans, Stone knew, were aware of the magnitude of the US research into chemical and biological warfare.

History of the science into the 1960s

Crichton spends time giving us some background on the development of science up till the 1960s: in particular how before, during and after the war, most expensive research focused on physics, in particular nuclear physics. But how, with the discovery of the structure of DNA in 1953, biology had exploded as a field of interest.

He gives us digressions on the nature of biology itself – ‘the only science which cannot define its subject matter’ because there is no agreed definition of LIFE. On the types of animals used in bio experiments – rats, monkeys, pigs – (p.146) or the large range of growth media used in laboratories (p.163). And an explanation for laymen of the symbiotic relationship between humans and the billions of bacteria we host, which leads on to a detailed explanation of the drawbacks which would occur if a wonderdrug were discovered which killed off all bacteria and viruses. In fact Crichton goes to the trouble of inventing a wonderdrug, Kalocin, for the purpose of the book which does just that – kills off all bacteria, viruses, fungi etc which inhabit the human body with the result that… all the human patients died (p.266). We need the bacteria which infest our bodies.

Man lives in a sea of bacteria (p.167)

Hard technology

And then there is the technology, which includes (obviously) the rocket technology used to launch the ill-fated space probe; NASA’s network of monitoring stations around the earth; and the technology used within the Wildfire biohazard installation, including state of the art sterilisation processes, spectrometers, amino-acid analysers, the microtome, the X-ray crystallographer, the electron microscope (a BVJ model JJ-42), Fourier electron-density scans and so on. He gives an explanation of why an electron microscope is better than a light one, as explained by one of its inventors (p.255).

Computers

Then there are computer diagnostics and computers in general. Crichton patiently explains to the 1969 reader that computers are capable of doing many tasks much faster than people! I’m always struck to be reminded just how long computers have been around and enthusiasts have been promising that they will change the world.

Commission of enquiry

All of this heavily factual material is organised as if in a report written up after the crisis was over and as the result of an inquiry into how it was handled. Thus the narrative itself contains mention of where the team made crucial mistakes.

  • It is a peculiarity of the Wildfire team that, despite the individual brilliance of the team members, the group grossly misjudged their information at several points. (p.243)
  • This was a most unfortunate decision, for had they examined the [growth] media, they would have seen that their thinking had already gone astray, and that they were on the wrong track. (p.250)

Scientific results

And the text includes numerous scientific illustrations, for example computer readouts of autopsies, chemical analyses of blood, a scanner printout from a ‘photoelectric eye’ that examined the growth media, an early sketch of the hexagonal structure of the Andromeda Strain, electron-density mapping of a sample of the strain – all carefully credited to Project Wildfire, as in a scientific paper.

The text is followed by four pages of finely printed references, mixing up genuine studies of extra-terrestrial life and biology with papers by the fictional characters in the novel.

Bureaucratic tone set in the preface

This approach, the pose that the entire text is an after-the-fact report, starts in the author’s preface, usually a place where the author is candid with the reader, but in this case Crichton presents himself as an investigator into the events surrounding the breakout, and gives copious thanks to numerous military officials who are entirely fictitious and are clearly part of the fictional cast, as if they were real figures.

The effect is partly to give the text verisimilitude but also allows him to do the standard thriller strategy of anticipating mistakes and accidents and disasters to come without going into detail and so making you impatient to read the full story itself.

Same happens when he describes the experiments the scientists carry out in the Wildfire lab and highlights their mistakes with phrases like ‘Only later would it become clear that…’ or ‘That was his first mistake…’, ‘It would be forty eight hours until he realised his error…’ (p.173)

Taken together, it’s all these tactics which give the novel its authoritative air and which, in turn makes the biological crisis all the more scary, and then the security breach at the centre all the more nailbiting.

Plot summary

By the end you realise that without all the images and diagrams and facts and figures in report format, and without the digressions about biology and computers, the book would have been significantly shorter, and the simpleness of the story much more apparent. Here is a barebones plot summary:

  • a space probe infected with alien life form crash lands near small town in Arizona, Piedmont
  • almost everyone in town dies almost immediately with weird symptoms, namely their blood congeals to powder
  • except two survivors, an old man and a screaming baby
  • they’re brought to a brand new hi-tech biohazard facility named after the project Wildfire where – after a thorough history of the thinking behind the centre, how it was researched, signed off, designed and built – the four scientists central to the story run a series of tests whose results are discussed at length, and engage in high-level speculations about the origin and form of the entity
  • there are several apparently unrelated incidents, mainly the crash of an air force jet which was flying high through airspace over Piedmont; crash investigators confirm the pilot’s last message which claimed that all the plane’s rubber hosing and casing was turning to powder
  • meanwhile the scientists have established that the Andromeda Strain, as it’s been named, consists of perfectly hexagonal crystals which replicate with amazing speed, and feed off pure energy, leaving no waste products
  • one of the scientists, the doctor, finally puts all the pieces of the jigsaw together and realises that the baby and the old man didn’t die because their blood PHs were abnormal, the old man because he was a diabetic, the baby because its continual crying acidated its blood – the Andromeda Strain only replicates within a narrow PH band
  • at just this moment the alarm goes off inside the bio centre indicating a seal has been broken sealing off the containment area, triggering the alarm and the countdown
  • countdown? yes, because throughout the novel we’ve been told that the Wildfire station has at its heart a thermonuclear device which will automatically detonate if there is a security leak – now the alarm bells go off, the red lights start flashing, all the big metal security doors slam shut and a nice lady’s voice starts counting down; they have three minutes before the bomb detonates!!
  • the thing is, it’s only been in the last hour or so that the scientists have realised that the strain feeds off pure light or energy – in other words, a nuclear explosion, far from wiping the virus out, will cause it to replicate a trillion-fold and spread all over America!!!
  • now, there is a failsafe, the nuclear countdown can be halted: the biohazard centre is dotted with light switch-sized sockets into which a metal key must be inserted to countermand the nuclear countdown, BUT the security doors clanging shut have sealed Dr Stone and Dr Hall off from any of these units – oops
  • which leads to the most famous passage in the book, and the movie based on it, when Dr Hall has to make his way through air ducts into the central circular core of the installation and climb up it to the next level, despite the fact that, given the security breach a) the central core is flooding with poison gas and b) remote control darts fire poisoned arrows at anything moving i.e. him
  • these last few pages are grippingly described as Hall tries to climb the ladder up inside the central shaft, despite becoming woozier and woozier, poisoned by the gas and hit by the poisoned darts, till he crashes through the door into the level above and staggers, almost unconscious to the nearest security point, inserts the key and turns it, then blacks out!!

Payoff

The virus mutates into a harmless form. Wind carries air from the now-leaking bio-hazard lab over Los Angeles but nothing at all happens. Lead scientist Stone speculates that a) it has mutated to a non-fatal form, as indicated by the way it had started eating rubber and plastic instead of human blood, and b) disliking oxygen rich environments (which earlier tests had established), it is likely to migrate upwards out of the atmosphere.

And that is the explanation for the brief two-page epilogue in which we learn that a recent manned space flight (Andros V) crash-lands killing all the crew. In an interview with journalists, the head of the program reveals the crash had something do with the failure of plastic safety shields. The journalists don’t know it, but we the readers know that this is proof that the Andromeda Strain has indeed gravitated away from the unfriendly oxygen-rich atmosphere of earth up to the troposphere – and the book ends with the threat that it might, possibly, remain there for ever, preventing the passage through it of any machines which contain rubber or plastic…

The IPCRESS connection

It’s fascinating to learn from Wikipedia that Crichton was heavily indebted to Len Deighton’s debut novel The IPCRESS File which was published in 1962 and which Crichton read on a visit to Britain.

The Deighton novel is also written in the style of an official report and recreates the often dull bureaucratic paperwork surrounding spying; the title itself indicates that the entire thing should be read as an official report.

Same with Andromeda which, on the pre-text pages, carries instructions as for an official file, which state: ‘THIS FILE IS CLASSIFIED TOP SECRET and that the ‘receiver’ of the file must first show his identity card to the courier.

All great boyish fun. I wonder if Crichton ever told Deighton about his indebtedness to him. I wonder what Deighton made of it.

Crystals

It’s interesting that the Andromeda Strain of virus turns out to be a perfect crystal and that one of the scientists is known for printing papers speculating that life on earth began as crystals (p.226). Because this is a genuine theory and is well expressed in the 1985 book, Seven Clues to the Origin of Life by A.G. Cairns-Smith (1985), which I read and reviewed not too long ago.

The movie

In 1971 The Andromeda Strain was made into a movie directed by Robert Wise and starring Arthur Hill as Stone, James Olson as Hall, Kate Reid as Leavitt (changed to a female character, Ruth Leavitt), and David Wayne as Dutton (Burton in the novel). A lot of its appeal is due to the fact it was low budget and not dominated by well-known Hollywood names, lending it an extra soupcon of credibility. I saw it as a kid and loved it.


Credit

The Andromeda Strain by Michael Crichton was published Knopf in American in 1969. All references are to the 1993 Arrow paperback edition.

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Seven Clues to the Origin of Life by A.G. Cairns-Smith (1985)

The topic of the origin of life on the Earth is a branch of mineralogy. (p.99)

How did life begin? To be more precise, how did the inorganic chemicals formed in the early years of planet earth, on the molten rocks or in the salty sea or in the methane atmosphere, transform into ‘life’ – complex organisms which extract food from the environment and replicate, and from which all life forms today are ultimately descended? What, when and how was that first momentous step taken?

Thousands of biologists have devoted their careers to trying to answer this question, with the result that there are lots of speculative theories.

Alexander Graham Cairns-Smith (1931-2016) was an organic chemist and molecular biologist at the University of Glasgow, and this 120-page book was his attempt to answer the Big Question.

In a nutshell he suggested that life derived from self-replicating clay crystals. To use Wikipedia’s summary:

Clay minerals form naturally from silicates in solution. Clay crystals, like other crystals, preserve their external formal arrangement as they grow, snap, and grow further.

Clay crystal masses of a particular external form may happen to affect their environment in ways that affect their chances of further replication. For example, a ‘stickier’ clay crystal is more likely to silt up a stream bed, creating an environment conducive to further sedimentation.

It is conceivable that such effects could extend to the creation of flat areas likely to be exposed to air, dry, and turn to wind-borne dust, which could fall randomly in other streams.

Thus – by simple, inorganic, physical processes – a selection environment might exist for the reproduction of clay crystals of the ‘stickier’ shape.

Cairns-Smith’s book is densely argued, each chapter like a lecture or seminar packed with suggestive evidence about what we know about current life forms, a summary of the principles underlying Darwin’s theory of evolution, and about how we can slowly move backwards along the tree of life, speculating about how it developed.

But, as you can see from the summary above, in the end, it is just another educated guess.

Detective story

The blurb on the back and the introduction both claim the book is written in the style of a detective story. Oh no it isn’t. It is written in the style of a biology book – more precisely, a biology book which is looking at the underlying principles of life, the kind of abstract engineering principles underlying life – and all of these take quite some explaining, drawing in examples from molecular biology where required.

Sometimes (as in chapter 4 where he explains in detail how DNA and RNA and amino acids and proteins interact within a living cell) it becomes quite a demanding biology book.

What the author and publisher presumably mean is that, in attempt to sweeten the pill of a whole load of stuff about DNA and ribosomes, Cairns-Smith starts every chapter with a quote from a Sherlock Holmes story and from time to time claims to be pursuing his goal with Holmesian deduction.

You see Holmes, far from going for the easy bits first, would positively seek out those features in a case that were seemingly incomprehensible – ‘singular’ features he would call them… I think that the origin of life is a Holmesian problem. (p.ix)

Towards the very end, he remembers this metaphor and talks about ‘tracking down the suspect’ and ‘making an arrest’ (i.e. of the first gene machine, the origin of life). But this light dusting of Holmesiana doesn’t do much to conceal the sometimes quite demanding science, and the relentlessly pedagogical tone of the book.

Broad outline

1. Panspermia

First off, Cairns-Smith dismisses some of the other theories about the origin of life. He makes short work of the theories of Fred Hoyle and Francis Crick that organic life might have arrived on earth from outer space, carried in dust clouds or on meteors etc (Crick’s version of this was named ‘Panspermia’) . I agree with Cairns-Smith that all variations on this hypothesis just relocate the problem somewhere else, but don’t solve it.

Cairns-Smith states the problem in three really fundamental facts:

  1. There is life on earth
  2. All known living things are at root the same (using the same carbon-based energy-gathering and DAN-replicating biochemistry)
  3. All known living things are very complicated

2. The theory of chemical evolution

In his day (the 1970s and 80s) the theory of ‘chemical evolution’ was widely thought to address the origin of life problem. This stated that lot of the basic amino acids and sugars which we find in organisms are relatively simple and so might well have been created by accident in the great sloshing oceans and lakes of pre-life earth, and that they then – somehow – came together to make more complex molecules which – somehow – learned how to replicate.

But it’s precisely on the vagueness of that ‘somehow’ that Cairns-Smith jumps. The leap from a random soup of semi-amino acids washing round in a lake and the immensely detailed and complex machinery of life demonstrated by even a tiny living organism – he selects the bacterium Escherichia coli – is just too vast a cliff face to have been climbed at random, by accident. It’s like saying if you left a bunch of wires and bits of metal sloshing around in a lake long enough they would eventually make a MacBook Air.

Cairns-Smith zeroes in on four keys aspects of life on earth which help to disprove the ‘chemical evolution’ theory.

  1. Life forms are complex systems. It is the whole machine which makes sense of its components.
  2. The systems are highly interlocked: catalysts are needed to make proteins, but proteins are needed to make catalysts; nucleic acids are needed to make proteins, yet proteins are needed to make nucleic acids;
  3. Life forms are very complex.
  4. The system is governed by rules and conventions: the exact choice of the amino acid alphabet and the set of assignments of amino acid letters to nucleic acid words are examples.

3. The Miller-Urey experiments

Cairns-Smith then critiques the theory derived from the Miller-Urey experiments.

In 1953 a graduate student, Stanley Miller, and his professor, Harold Urey, performed an experiment that demonstrated how organic molecules could have spontaneously formed from inorganic precursors, under conditions like those posited by the Oparin-Haldane Hypothesis. The now-famous ‘Miller–Urey experiment’ used a highly reduced mixture of gases – methane, ammonia and hydrogen – to form basic organic monomers, such as amino acids. (Wikipedia)

Cairns-Smith spends four pages comprehensively demolishing this approach by showing that:

  1. the ultraviolet light its exponents claim could have helped synthesise organic molecules is in fact known to break covalent bonds and so degrade more than construct complex molecules
  2. regardless of light, most organic molecules are in fact very fragile and degrade easily unless kept in optimum conditions (i.e. inside a living cell)
  3. even if some organic molecules were created, organic chemists know only too well that there are hundreds of thousands of ways in which carbon, hydrogen, nitrogen and oxygen can combine, and most of them result in sticky sludges and tars in which nothing could ‘live’

So that:

  1. Only some of the molecules of life can be made this way
  2. Most of the molecules that would be made this way are emphatically not the ‘molecules of life’
  3. The ‘molecules of life’ are usually better made under conditions far most favourable than those obtaining back in the primordial soup era

He then does some back-of-a-matchbox calculations to speculate about how long it would take a random collection of organic molecules to ‘happen’ to all tumble together and create a life form: longer than the life of the universe, is his conclusion. No, this random approach won’t work.

Preliminary principles

Instead, he suggests a couple of principles of his own:

  1. That some and maybe all of the chemicals we now associate with ‘life’ were not present in the first replicating organisms; they came later; their exquisitely delicate interactivity suggests that they are the result not the cause of evolution
  2. Therefore, all lines of investigation which seek to account for the presence of the molecules of life are putting the cart before the horse: it isn’t the molecules which are important – it is the mechanism of replication with errors

Cairns-Smith thinks we should put the molecules of life question completely to one side, and instead seek for entirely inorganic systems which would replicate, with errors, so that the errors would be culled and more efficient ways of replicating tend to thrive on the available source material, beginning to create that dynamism and ‘sense of purpose’ which is one of life’s characteristics.

We keep coming to this idea that at some earlier phase of evolution, before life as we know it, there were other kinds of evolving system, other organisms that, in effect, invented our system. (p.61)

This seems, intuitively, like a more satisfying approach. Random forces will never make a MacBook Air and, as he has shown in chapter 4, even an entity like Escherichia coli is so staggeringly complex and amazingly finely-tuned as to be inconceivable as the product of chance.

Trying to show that complex molecules like ribosomes or RNA or amino acids – which rely on each other to be made and maintained, which cannot exist deprived of the intricately complicated interplay within each living cell – came about by chance is approaching the problem the wrong way. All these complex organic molecules must be the result of evolution. Evolution itself must have started with something much, much simpler – with the ‘invention’ of the basic engine, motor, the fundamental principle – and this is replication with errors. In other words:

Evolution started with ‘low-tech’ organisms that did not have to be, and probably were not made from, ‘the molecules of life’. (p.65)

Crystals

And it is at this point that Cairns-Smith introduces his Big Idea – the central role of clay crystals – in a chapter titled, unsurprisingly, ‘Crystals’ (pp.75-79).

He now explains in some detail the surprisingly complicated and varied world of clay crystals. These naturally form in various solutions and, if splashed up onto surfaces like rocks or stones, crystallise out into lattices, but the crystallisation process also commonly involves errors and mutations.

His description of the different types of crystals and their properties is fascinating – who knew there were so many types, shapes, patterns and processes, starting with an introduction to the processes of saturation and super-saturation. The point is that crystals naturally occur and naturally mutate. He lists the ways they can vary or diverge from their ‘pure’ forms: twinning, stacking errors, cation substitutions, growth in preferred directions, break-up along preferred planes (p.97).

There follows a chapter about the prevalence of crystals in mud and clay and, therefore, their widespread presence in the conditions of the early planet earth.

And then, finally, he explains the big leap whereby replicating crystals may have attracted to themselves other molecules.

There follows a process of natural selection for clay crystals that trap certain forms of molecules to their surfaces that may enhance their replication potential. Complex proto-organic molecules can be catalysed by the surface properties of silicates.

Genetic takeover of the crystals

It is at this point that he introduces the idea of a ‘genetic takeover’.

When complex molecules perform a ‘genetic takeover’ from their clay ‘vehicle’, they become an independent locus of replication – an evolutionary moment that might be understood as the first exaptation.

(Exaptation = ‘the process by which features acquire functions for which they were not originally adapted or selected’)

Cairns-Smith had already described this process – the ‘genetic takeover’ of an initial, non-organic process by more complex, potentially organic molecules – in his earlier, longer and far more technical book, Genetic Takeover: And the Mineral Origins of Life, published in 1982.

This book – the Seven Clues – is a much shorter, non-technical and more accessible popularisation of the earlier tome. Hence the frivolous references to Sherlock Holmes.

Proliferating crystals form the scaffold for molecules which learn to replicate without them

The final chapter explains how these very common and proliferating entities (clay crystals) might have formed into structures and arrangements which attracted – for purely chemical reasons – various elementary organic molecules to themselves.

Certain repeating structures might attract molecules which then build up into more complex molecules, into molecules which are more efficient at converting the energy of the sun into further molecular combinations. And thus the principle of replication with variation, and competition for resources among the various types of replicating molecule, would have been established.

Thoughts

At this point the book ends, his case presented. It has been a fascinating journey because a) it is interesting to learn about all the different shapes and types of clay crystal b) he forces the reader to think about the fundamental engineering and logistical aspects of life forms, to consider the underlying principles which must inform all life forms, which is challenging and rewarding.

But, even in his own terms, Cairns-Smith’s notion of more and more complex potentially organic molecules being haphazardly replicated on a framework of proliferating clay crystals is still a long, long, long way from even the most primitive life forms known to us, with their vastly complex structure of cell membrane, nucleus and internal sea awash with DNA-controlled biochemical processes.


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